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It is thought to positively affect communication between nerve cells in the central nervous system and/or restore chemical balance in the brain “In general, generics have been as effective as brand-name antidepressants. It also investigates any problems or complaints, and when needed, will issue recalls both for brand-name and generic drugs. 2 out of 10 from a total of 224 ratings on Drugs. View all 2035 reviews View all 1816 reviews Drug Class Selective serotonin reuptake inhibitors Tetracyclic antidepressants Side Effects. Note: Food and Drug Administration (FDA) assures that all approved generic medicines work in the same way and provide the same clinical benefits and risks as their brand-name counterparts Mirtazapine is used to treat depression. The way mirtazapine works is still not fully understood. 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