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Take with food or on an empty stomach does not affect lisinopril. 61 mg per kg of body weight or 40 mg per day. Lisinopril is a medical drug that classifies as an ACE (Angiotensin-converting enzyme) inhibitor that targets relaxing your blood vessels so that your blood can flow more smoothly. Usually dosage of Lisinopril is prescribed without regard to meals. Children younger than 6 years of age—Use is not recommended. Lisinopril with or without food, does it matter? After the very first dose, you can take lisinopril at any time of day. Talk to your care team about the use of this medication in children. Created for people with ongoing healthcare needs but benefits everyone.. Caution with potassium salts and suppleme. Adults—At first, 5 milligrams (mg) once a day. Do not use salt substitutes or potassium supplements while taking lisinopril, unless your doctor has told you to Potassium Rich Foods: Lisinopril has the capacity to increase blood potassium level which can lead to irregular heartbeat. Foods to avoid in excess include bananas, oranges, potatoes, tomatoes, squash, and dark leafy greens. It doesn't matter - lisinopril tablets and liquid can be taken either with or without food, on a full or empty stomach. Not everyone taking lisinopril needs to limit potassium, sodium, alcohol, calories or fat.